Diapositiva 1

= Sono cellule = indifferenziate: <= /span>

= • Si possono = dividere senza = = limite

<= span style=3D'font-family:"Malgun Gothic";font-size:133%;color:white;text-shado= w: auto'>• Possono dare origine a progenie = differenziata

COSA SONO LE CELLULE STAMINALI?

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CE= LLU= LE ST<= span style=3D'font-size:133%;color:white'>AMI= NAL= I

EMBRIONALI

(pluripotenti)

ADULTE

Multipotenti o unipotenti

Vietato l’uso in Italia

Ottenute dopo la nascita:

a)d= al midollo osseo

b)d= al tessuto

c)d= al cordone ombel= icale

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CELLULE STAMINALI DEL CORDONE OMBELICALE=

Sono staminali adulte ottenute dal sangue cordonale dopo il parto

Il sangue cordonale (e le cellule staminali contenute in ess= o), viene raccolto dal personale ostetrico

La procedura di raccolta del sangue cordonale è assolutamente innocua sia per la mamma che per il bambino <= /span>

La raccolta del sangue cordonale avviene = dopo il taglio del cordone= e l’allontanamento del bambino

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LE CELLULE STAMINALI DEL CORDONE OMBELICALE

Possono essere conservate dopo la raccolta

(DONAZIONE)

CONSERVAZIONE AUTOLOGA

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CONSERVAZIONE <= /b>= ETEROLOGA

=

v Le cellule vengono donate dopo la raccolta post parto, conservate in banche pubbliche e = messe a disposizione di riceventi non <= /span>consanguinei = compatibili (malattie = ematologiche)

v=

v Sono quindi destinate <= /span>all’utilizzo da part= e di riceventi non consanguinei

CONSERVAZIONE <= /b>AUTOLOGA

=

v Le cellule vengono raccolte e conservate = per un eventuale futuro utilizzo da parte <= /b>del donatore stesso o = di consanguinei compatibili (genitori, fratelli…) <= /span>

v=

v Sono quindi destinate <= /span>all’utilizzo sullo stesso donatore (o consanguinei: eterologa ristretta)

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CONSERVAZIONE ETEROLOGA

1.Nessun costo per = il donatore

2.

2.Gesto altruistico =

3.

3.Rende disponibili cellule per riceventi senza = donatori familiari = compatibili

1.Impossibilità di rientrare in possesso del campione in caso di necessità= 3;

2.

2.Utilizzo ristretto alle patologie ematologiche = (sostituzione del trapianto= di midollo) =

3.

= 3.Il 40% dei pazienti in atte= sa di trapianto trovano un donatore compatibile e di <= /b>questi il 50% va incontro a= rigetto

VANTAGGI

SVANTAGGI

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CONSERVAZIONE AUTOLOGA

1.Campione = disponibile in ogni momento

2.

2.Nessun problema <= span style=3D'font-family:"Malgun Gothic";mso-ascii-font-family:"Malgun Gothic"; font-size:106%;text-shadow:auto;color:white'>di incompatibilità&= #13;

3.

3.Utilizzo per = patologie diverse non solo = ematologiche

4.

4.Evoluzione della = ricerca<= /div>

1.Costo a carico dei genitori

= 2. = ;

= 2. = ;

2.Legislazione ital= iana: rivolgersi a stru= tture estere e lunghi iter burocratici

= 3. = ;

3.Distribuzione eterogenea delle strutture in grado di eseguire il preli= evo

VANTAGGI

SVANTAGGI

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POSSIBILITAR= 17; DI UTILIZZO CELLULE CONSERVATE CON USO AUTOLOGO

ATTUALI

<= span style=3D'font-family:"Malgun Gothic";font-size:111%;color:white;text-shado= w: auto'>Ø Malattie ematologiche

<= span style=3D'font-family:"Malgun Gothic";font-size:111%;color:white;text-shado= w: auto;visibility:hidden'>Ø

<= span style=3D'font-family:"Malgun Gothic";font-size:111%;color:white;text-shado= w: auto'>Ø Alcune patol= ogie autoimmuni

<= span style=3D'font-family:"Malgun Gothic";font-size:111%;color:white;text-shado= w: auto;visibility:hidden'>Ø

<= span style=3D'font-family:"Malgun Gothic";font-size:111%;color:white;text-shado= w: auto'>Ø Alcune patol= ogie ereditarie

<= span style=3D'font-family:"Malgun Gothic";font-size:111%;color:white;text-shado= w: auto;visibility:hidden'>Ø

<= span style=3D'font-family:"Malgun Gothic";font-size:111%;color:white;text-shado= w: auto'>Ø Cardiopatia ischemica

=

POTENZIALI O FUTURE

= ;

<= span style=3D'position:absolute;top:37.75%;left:63.85%;width:31.08%;height:4.5%= '>ØTrattamento di patologie degener= ative (SLA, Parkinson..= )

<= span style=3D'font-size:111%;color:white;text-shadow:auto;visibility:hidden'>Ø

<= span style=3D'position:absolute;top:55.5%;left:63.85%;width:31.08%;height:4.5%'= >ØRiparazione o rigenerazione dei= tessuti <= /span>

<= span style=3D'font-size:111%;color:white;text-shadow:auto;visibility:hidden'>Ø

<= span style=3D'font-size:111%;color:white;text-shadow:auto'>ØTerapia cellulare=

<= span style=3D'font-size:111%;color:white;text-shadow:auto;visibility:hidden'>Ø

<= span style=3D'font-size:111%;color:white;text-shadow:auto'>ØTerapia genica

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CONSERVAZIONE AUTOLOGA:

LEGISLAZIONE ITALIANA

- <= /span>La legislazione italiana v= ieta l’istituzione in Italia di banche private per la conservazio= ne delle staminali

-<= /span>

- Le banche pubbliche offrono la sola conservazione eterologa

-<= /span>

- In Italia non è di fatto possibile la conservazione autologa

-<= /span>

La legislazione permette però l’esportazione all’estero delle cellule staminali ai fini= della conservazione autologa in strutture private autorizzate <= /b>
= ;

L’esportazi= one è regolata da un preciso iter burocratico

DOPO IL 28 FEBBRAIO 2009 SARA’ FORSE POSSIBILE CONSERVARE IN ITALIA

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StemCellsMedicalService

Servizio sviluppato da I.M.S. Innovative Medical Solutions

concepito per consentire ai genitori italiani di = conservare le cellule staminali per uso autologo presso una struttura estera autorizzata situata nella Comunità Euro= pea

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IL SERVIZIO STEP BY STEP:

=

1) Informazio= ne sul servizio via internet, attraverso colloquio con il ginecologo o attraverso telefonata al numero = verde 800 03 45 = 58

Adesione al servizio e sottoscrizione del Contratto almeno 40 giorni prima della data presunta del parto

=

Il Contratto viene inviato su richiesta = telefonica o tramite e-mai= l

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2) Trenta giorni prima della data = presunta del parto la madre deve <= /b>= sottoporsi ad un prelievo del = sangue per determinare i seguenti = marker sierologici:

HIV 1/2

HTLV 1/2

= 3;

HBsAg

AntiHBc

AntiHCV

Anti-CMV

TPHA

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3) Invio a domicilio di StemCellsMedicalServiceK= it,
il kit per la raccolta e l’invio del sangue cordonale, costituito da:<= /span>

- sacca sterile per raccolta a 2 aghi contenente CPD =

- contenitore rigido <= /span>secondario con chiusura ermetica contenente carta = assorbente =

- contenitore in EPS per mantenere la temperatura <= /b>del kit costante =

- siberini per il controll= o della temperatura =

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4) Iter burocratico: <= /b>

- Richiesta alla Direzione Sanitaria dell’ospedale prescelto

<= span style=3D'font-family:"Malgun Gothic";font-size:111%;color:white;text-shado= w: auto'>- Counseling con il Centro Nazionale Trapianti

<= span style=3D'font-family:"Malgun Gothic";font-size:111%;color:white;text-shado= w: auto'>- Richiesta nulla osta al Ministero = della Salute

5) In caso l’ospedal= e lo ritenga opportuno,vengono organizzati corsi al personale ostetrico = per l’utilizzo del kit di raccolta. Attualmente, la maggior parte d= egli ospedali italiani ha eseguito la procedura ed esegue correttamente il prelievo.

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6) Al momento del parto:&#= 13;

- Portare in ospedale il kit ed avvi= sare telefonicamente la nostra Assistenza Clienti= 3;
<= span style=3D'font-family:"Malgun Gothic";font-size:111%;color:white;text-shado= w: auto'>- Il personale esegue il prelievo= 3;
- Comunicare alla nostra Assistenza Clienti l’avvenuto prelievo - L’Assistenza Clienti organiz= za il ritiro del campione in ospedale ed il trasferimento in laboratorio

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7) Il campione di sangue cordonale giunge presso i laboratori = situati in Germania, dove viene manipolato e conservato in contenitori criogenici a vapori di azoto

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1.Determinazione del volume = di sangue raccolto:

V <40 ml: volume insufficiente, i geni= tori ottengono il rimborso

V >40 ml: il campione viene manipolato ed in base al volume finale conservato in una o due sacche

2.Manipolazione del campione= con Sepax in camera sterile

8) In laboratorio:

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3.

<= span style=3D'font-family:"Malgun Gothic";font-size:111%;color:white;font-weigh= t: bold;text-shadow:auto'>4.Preparazione della soluzione crioprotettiva

<= span style=3D'font-family:"Malgun Gothic";font-size:111%;color:white;font-weigh= t: bold;text-shadow:auto;visibility:hidden'>5.

<= span style=3D'font-family:"Malgun Gothic";font-size:111%;color:white;font-weigh= t: bold;text-shadow:auto'>5.Congelamento del campione

3.Preparazione delle provett= e da dedicare ai vari test: = ; emocromo, determinazione del gruppo, tipizzazione HLA, esami di biochimica clinica e conta assoluta di cellule CD34 (citometria&= nbsp; a flusso)

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6.Completamento dei test di laboratorio nei trenta giorni successivi

= 7.I Genitori ricevono la certificazione di avvenuta conservazione

8.Sei mesi dopo: la madre de= ve sottoporsi ad un nuovo prelievo del sangue per ripetere la determinazione dei marker sierologici

9.Il Campione rimane conserv= ato per 20 anni, dopo i quali è eventualmente possibile il rinnovo.

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=

In caso di necessità di utilizzo,= il campione di cellule staminali conservato in laboratorio verrà immediatamente spedito in un dry-shipper appositamente studiato tramite corriere specializzato presso la struttura o l’ospe= dale indicato

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Costi:

2.250,00 €, tutto compreso per 20 an= ni di conservazione

Tre diverse modalità di pagamento:

1)250,00 € all’adesione e 2.000,00 dopo il parto

2)2.150,00 € all’adesione <= /b>

3)250,00 € all’adesion= e e 2.000,00 in 8 rate da 250,00 € senza interessi =

4)
Parto gemellare:

3.600,00 €, tutto compreso per 20 anni di conservazi= one

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= GRAZIE PER L’ATTENZIONE!

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Fare clic per uscire.", SCREE= N_MODE=3D"Frames", gIsEndShow=3D0, NUM_VIS_SLDS=3D24, SCRIPT_HREF=3D"script= .js", FULLSCR_HREF=3D"fullscreen.htm"; var gCurSld =3D gPrevSld =3D 1, g_offset =3D 0, gNtsOpen =3D gHasNts =3D gO= tlTxtExp =3D 0, gHasNarration =3D 0, gOtlOpen =3D true window.gPPTHTML=3DSupportsPPTHTML() var g_fBaseHyperlink =3D false; var gMainDoc=3Dnew Array(new hrefList("slide0022.htm",1,-1,1),new hrefList(= "slide0001.htm",1,-1,1),new hrefList("slide0002.htm",1,-1,1),new hrefList("= slide0024.htm",1,-1,1),new hrefList("slide0003.htm",1,-1,1),new hrefList("s= lide0004.htm",1,-1,1),new hrefList("slide0005.htm",1,-1,1),new hrefList("sl= ide0006.htm",1,-1,1),new hrefList("slide0007.htm",1,-1,1),new hrefList("sli= de0008.htm",1,-1,1),new hrefList("slide0012.htm",1,-1,1),new hrefList("slid= e0013.htm",1,-1,1),new hrefList("slide0014.htm",1,-1,1),new hrefList("slide= 0015.htm",1,-1,1),new hrefList("slide0016.htm",1,-1,1),new hrefList("slide0= 017.htm",1,-1,1),new hrefList("slide0025.htm",1,-1,1),new hrefList("slide00= 19.htm",1,-1,1),new hrefList("slide0018.htm",1,-1,1),new hrefList("slide002= 0.htm",1,-1,1),new hrefList("slide0026.htm",1,-1,1),new hrefList("slide0021= .htm",1,-1,1),new hrefList("slide0027.htm",1,-1,1),new hrefList("slide0023.= htm",1,-1,1)); /********************************************* Frameset functions These functions control slide navigation and state of the frameset. **********************************************/ function RemoveFilePrefixFromHref(href) { var regExp =3D /^file:\/\/\//i; return href.replace(regExp, "") } function FullScrInit() { g_allowAdvOnClick =3D GetCurSld().mAdvOnClk document.body.style.backgroundColor=3D"black" document.oncontextmenu=3Dparent._CM; document.onkeydown =3D _KDH; document.ondragstart=3DCancel document.onselectstart=3DCancel self.focus() } function Redirect( frmId ) {=09 var str=3Ddocument.location.hash,idx=3Dstr.indexOf('#'), sId=3DGetSldId() if(idx>=3D0) str=3Dstr.substr(1); if( window.name !=3D frmId && ( sId !=3D str) ) { obj =3D GetObj("Main-File") window.location.href=3Dobj.href+"#"+sId return 1 } return 0 } var MHTMLPrefix =3D CalculateMHTMLPrefix();=20 function CalculateMHTMLPrefix() { if ( document.location.protocol =3D=3D 'mhtml:') {=20 href=3Dnew String(document.location.href)=20 Start=3Dhref.indexOf('!')+1=20 End=3Dhref.lastIndexOf('/')+1=20 if (End < Start)=20 return href.substring(0, Start)=20 else=20 return href.substring(0, End)=20 } return ''; } function GetTags(base,tag) { if(g_supportsPPTHTML) return base.all.tags(tag); else return base.getElementsByTagName(tag); } function UpdNtsPane(){ if(frames["PPTNts"]) PPTNts.location.replace( MHTMLP= refix+GetHrefObj( gCurSld ).mNtsHref ) } function UpdNavPane( sldIndex ){ if(gNavLoaded) PPTNav.UpdNav() } function UpdOtNavPane(){ if(gOtlNavLoaded) PPTOtlNav.UpdOtlNav() } function UpdOtlPane(){ if(gOtlLoaded) PPTOtl.UpdOtl() } function SetHasNts( fVal ) { if( gHasNts !=3D fVal ) { gHasNts=3DfVal UpdNavPane() } } function ToggleOtlText() { gOtlTxtExp=3D!gOtlTxtExp UpdOtlPane() } function ClearMedia() { // Clear any sounds playing before launching another browser window. Other= wise, // in fullscreen mode, you'll continue to hear the sound in the frames mod= e. if (PPTSld.pptSound) PPTSld.pptSound.loop =3D 0; } function FullScreen() {=20 if ( PPTSld.g_animUseRuntime ) PPTSld.document.body.pause(); ClearMedia(); var href =3D ( document.location.protocol =3D=3D 'mhtml:') ? FULLSCR_HREF = : FULLSCR_HREF+"#"+GetHrefObj(gCurSld).mSldHref; if (MHTMLPrefix !=3D "") href =3D RemoveFilePrefixFromHref(href) if(PPTNav.event.ctrlKey) { var w =3D (window.screen.availWidth * 1.0) / 2.0 var h =3D w * (PPTSld.g_origH * 1.0) / PPTSld.g_origW win =3D window.open( MHTMLPrefix+href,null,"toolbar=3D0,resizable=3D1,top= =3D0,left=3D0," + "width=3D"+ w + ",height=3D" + h ); if( win.document.body && PPTSld.g_animUseRuntime ) win.document.body.PPTSldFrameset=3Dwindow; } else { win =3D window.open( MHTMLPrefix+href,null,"fullscreen=3Dyes" ); if( win.document.body && PPTSld.g_animUseRuntime ) win.document.body.PPTSldFrameset=3Dwindow; } } function ToggleVNarration() { rObj=3DPPTSld.document.all("NSPlay") if( rObj && !PPTSld.g_animUseRuntime ) { if( (rObj.playState =3D=3D 1)||(rObj.playState =3D=3D 0) ) rObj.Play() else if( rObj.playState =3D=3D 2 ) rObj.Pause() else return; } else if( PPTSld.g_animUseRuntime ) { narObj =3D PPTSld.document.all("narrationID") if( narObj ) narObj.togglePause() } } function GetCurSldNum() { =20 obj=3DGetHrefObj(gCurSld) if( obj.mOrigVis =3D=3D 1 ) return obj.mSldIdx else =20 return gCurSld } function GetNumSlds() { =20 if( GetHrefObj(gCurSld).mOrigVis =3D=3D 1 ) return GetSldList().mNumVisSlds; else return GetSldList().mList.length } function GetSldNum( href ) { for(ii=3D0; ii 1 ) PopSldList(); else if( !IsFramesMode() ) { if( gLoopCont ) GoToFirst() else EndShow() } } function GoToPrevSld() { ii=3DgCurSld-1 if( ii > 0 ) { obj=3DGetHrefObj(ii) while ( obj && ( obj.mVis =3D=3D 0 ) && ( ii>0 ) ) obj=3DGetHrefObj(--ii) if( ii =3D=3D 0 ) ii=3D1 GoToSldNum(ii) } } function GoToFirst(){ GoToSld( GetHrefObj(1).mSldHref ) } function GoToLast() { ii=3DGetSldList().mList.length if( ii !=3D gCurSld ) GoToSld( GetHrefObj(ii).mSldHref ) } function GoToSldNum( num ) { if( PPTSld.event ) PPTSld.event.cancelBubble=3Dtrue obj =3D GetHrefObj( num ) obj.mVis=3D1 gPrevSld=3DgCurSld gCurSld =3D num; =09 if (MHTMLPrefix !=3D "") PPTSld.location.replace(MHTMLPrefix+RemoveFilePrefixFromHref(obj.mSldHref= )) else PPTSld.location.replace(obj.mSldHref) =09 if( IsFramesMode() ) { UpdNavPane(); UpdOtlPane(); UpdNtsPane() } } function GoToSld( href ) { if( PPTSld.event ) PPTSld.event.cancelBubble=3Dtrue GetHrefObj( GetSldNum(href) ).mVis=3D1 if (MHTMLPrefix !=3D "") PPTSld.location.replace(MHTMLPrefix+RemoveFilePrefixFromHref(href)) else PPTSld.location.replace(href) } function SldUpdated( id ) { if( id =3D=3D GetHrefObj(gCurSld).mSldHref ) return gPrevSld=3DgCurSld gCurSld=3DGetSldNum(id) if( IsFramesMode() ) { UpdNavPane(); UpdOtlPane(); UpdNtsPane() } } function PrevSldViewed(){ GoToSld( GetHrefObj(gPrevSld).mSldHref ) } function HasPrevSld() { return ( gIsEndShow || ( gCurSld !=3D 1 && GetHrefO= bj( gCurSld-1 ).mVis =3D=3D 1 )||( GetCurSldNum() > 1 ) ) } function HasNextSld() { return (GetCurSldNum() !=3D GetNumSlds()) } function CloseWindow() { if( HideMenu() ) return; =09 var event =3D PPTSld.event; if( !IsFramesMode() && event && (event.keyCode=3D=3D27 || event.keyCode=3D= =3D32 || event.type=3D=3D"click" ) ) window.close( self ); CatchNumKeys( self, event ); } function Unload() { gIsEndShow=3D0; } function SetupEndShow() { gIsEndShow=3D1; PPTSld.document.body.scroll=3D"no"; PPTSld.document.onkeypress=3DCloseWindow; PPTSld.document.onclick=3DCloseWindow; PPTSld.document.oncontextmenu=3D_CM; } function EndShow() { if( IsFramesMode() ) return if( PPTSld.event ) PPTSld.event.cancelBubble=3Dtrue doc=3DPPTSld.document var dir =3D doc.body.dir if( dir !=3D "rtl" ) dir =3D "ltr"; doc.open() doc.writeln('

' + ENDSHOW_MESG + '
') doc.close() } function SetSldVisited(){ GetSldList().mList[gCurSld-1].mVisited=3Dtrue } function IsSldVisited(){ return GetSldList().mList[gCurSld-1].mVisited } function hrefList( sldHref, visible, advDelay, advClk ) { this.mSldHref=3D this.mNtsHref =3D sldHref this.mOrigVis=3D this.mVis =3D visible this.mVisited=3D false this.mAdvDelay=3D advDelay this.mAdvOnClk=3D advClk } function SldList(arr,curSld,fEnd) { this.mCurSld =3D curSld; this.mList =3D new Array(); var idx =3D 1; for(ii=3D0;ii 0) { PushSldList(sldList,fEnd); gCurSld =3D 1; } else if( PPTSld.event ) PPTSld.event.cancelBubble=3Dtrue } function PushSldList(arr,fEnd) { var ii =3D gSldStack.length; gSldStack[ii] =3D new SldList(arr,gCurSld,fEnd); GoToSld( gSldStack[ii].mList[0].mSldHref ); } function PopSldList() { if (gSldStack[gSldStack.length-1].fEndShow) EndShow() else { gCurSld =3D gSldStack[gSldStack.length-1].mCurSld; gSldStack[gSldStack.length-1] =3D null; gSldStack.length--; var sldList =3D gSldStack[gSldStack.length-1]; GoToSld( sldList.mList[gCurSld - 1].mSldHref ); } } var custShowList=3Dnew Array(); /********************************************* Navigation button implementation There are 2 types of buttons: ImgBtn, TxtBtn implemented as function objects. They share a similiar interface so the event handlers can call SetActive, for example, on a button=20 object without needing to know exactly=20 what type of button it is. **********************************************/ //---------------------------------- function ImgBtn( oId,bId,w,action ) //---------------------------------- { var t=3Dthis t.Perform =3D _IBP t.SetActive =3D _IBSetA t.SetInactive=3D _IBSetI t.SetPressed =3D _IBSetP t.SetDisabled=3D _IBSetD t.Enabled =3D _IBSetE t.ChangeIcon =3D null t.UserAction =3D action t.ChgState =3D _IBUI t.mObjId =3D oId t.mBorderId=3D bId t.mWidth =3D w t.mIsOn =3D t.mCurState =3D 0 } function _IBSetA() { if( this.mIsOn ) { obj=3Dthis.ChgState( gHiliteClr,gShadowClr,2 ) obj.style.posTop=3D0 } } function _IBSetI() { if( this.mIsOn ) { obj=3Dthis.ChgState( gFaceClr,gFaceClr,1 ) obj.style.posTop=3D0=20 } } function _IBSetP() { if( this.mIsOn ) { obj=3Dthis.ChgState( gShadowClr,gHiliteClr,2 ) obj.style.posLeft+=3D1; obj.style.posTop+=3D1 } } function _IBSetD() { =20 obj=3Dthis.ChgState( gFaceClr,gFaceClr,0 ) obj.style.posTop=3D0=20 } function _IBSetE( state ) { var t=3Dthis GetObj( t.mBorderId ).style.visibility=3D"visible" if( state !=3D t.mIsOn ) { t.mIsOn=3Dstate if( state ) t.SetInactive() else t.SetDisabled() } } function _IBP() { var t=3Dthis if( t.mIsOn ) { if( t.UserAction !=3D null ) t.UserAction() if( t.ChangeIcon ) { obj=3DGetObj(t.mObjId) if( t.ChangeIcon() ) obj.style.posLeft=3Dobj.style.posLeft+(t.mCurState-4)*t.mWidth else obj.style.posLeft=3Dobj.style.posLeft+(t.mCurState-0)*t.mWidth } t.SetActive() } =20 } function _IBUI( clr1,clr2,nextState ) { var t=3Dthis SetBorder( GetObj( t.mBorderId ),clr1,clr2 ) obj=3DGetObj( t.mObjId ) obj.style.posLeft=3Dobj.style.posLeft+(t.mCurState-nextState)*t.mWidth-obj= .style.posTop t.mCurState=3DnextState return obj } //----------------------------------------- function TxtBtn( oId,oeId,action,chkState ) //----------------------------------------- { var t=3Dthis t.Perform =3D _TBP t.SetActive =3D _TBSetA t.SetInactive=3D _TBSetI t.SetPressed =3D _TBSetP t.SetDisabled=3D _TBSetD t.SetEnabled =3D _TBSetE t.GetState =3D chkState t.UserAction =3D action t.ChgState =3D _TBUI t.mObjId =3D oId t.m_elementsId=3D oeId t.mIsOn =3D 1 } function _TBSetA() { var t=3Dthis if( t.mIsOn && !t.GetState() ) t.ChgState( gHiliteClr,gShadowClr,0,0 ) } function _TBSetI() { var t=3Dthis if( t.mIsOn && !t.GetState() ) t.ChgState( gFaceClr,gFaceClr,0,0 ) } function _TBSetP() { if( this.mIsOn ) this.ChgState( gShadowClr,gHiliteClr,1,1 ) } function _TBSetD() { =20 this.ChgState( gFaceClr,gFaceClr,0,0 ) this.mIsOn =3D 0 } function _TBSetE() { var t=3Dthis if( !t.GetState() ) t.ChgState( gFaceClr,gFaceClr,0,0 ) else t.ChgState( gShadowClr,gHiliteClr,1,1 ) t.mIsOn =3D 1 } function _TBP() { var t=3Dthis if( t.mIsOn ) {=20 if( t.UserAction !=3D null ) t.UserAction() if( !t.GetState ) return if( t.GetState() ) t.SetPressed() else t.SetActive() } =20 } function _TBUI( clr1,clr2,lOffset,tOffset ) { SetBorder( GetObj( this.mObjId ),clr1,clr2 ) Offset( GetObj( this.m_elementsId ),lOffset,tOffset ) } function Offset( obj, top, left ){ obj.style.top=3Dtop; obj.style.left=3Dle= ft } function SetBorder( obj, upperLeft, lowerRight ) { s=3Dobj.style; s.borderStyle =3D "solid" s.borderWidth =3D 1=20 s.borderLeftColor =3D s.borderTopColor =3D upperLeft s.borderBottomColor=3D s.borderRightColor =3D lowerRight } function GetBtnObj(){ return gBtnArr[window.event.srcElement.id] } function BtnOnOver(){ b=3DGetBtnObj(); if( b !=3D null ) b.SetActive() } function BtnOnDown(){ b=3DGetBtnObj(); if( b !=3D null ) b.SetPressed() } function BtnOnOut(){ b=3DGetBtnObj(); if( b !=3D null ) b.SetInactive() } function BtnOnUp() { b=3DGetBtnObj() if( b !=3D null ) b.Perform() else Upd() } function GetNtsState(){ return parent.gNtsOpen } function GetOtlState(){ return parent.gOtlOpen } function GetOtlTxtState(){ return parent.gOtlTxtExp } function NtsBtnSetFlag( fVal ) { s=3Ddocument.all.item( this.m_flagId ).style s.display=3D"none" if( fVal ) s.display=3D"" else s.display=3D"none" } function _BSetA_Border(){ b =3D gBtnArr[this.mObjId]; if( b !=3D null ) b.S= etActive() } function _BSetI_Border(){ b =3D gBtnArr[this.mObjId]; if( b !=3D null ) b.S= etInactive() } function _BSetP_Border(){ b =3D gBtnArr[this.mObjId]; if( b !=3D null ) b.S= etPressed() } function _BSetA_BorderImg() {=20 b =3D gBtnArr[this.mBorderId]=20 if( b !=3D null && this.mIsOn && !b.GetState() ) { obj=3Dthis.ChgState( gHiliteClr,gShadowClr,2 ) obj.style.posTop=3D0 } } function _BSetI_BorderImg() {=20 b =3D gBtnArr[this.mBorderId] if( b !=3D null && this.mIsOn && !b.GetState() ) { obj=3Dthis.ChgState( gFaceClr,gFaceClr,1 ) obj.style.posTop=3D0 } } var gHiliteClr=3D"THREEDHIGHLIGHT",gShadowClr=3D"THREEDSHADOW",gFaceClr=3D"= THREEDFACE" var gBtnArr =3D new Array() gBtnArr["nb_otl"] =3D new TxtBtn( "nb_otl","nb_otlElem",parent.ToggleOtlPan= e,GetOtlState ) gBtnArr["nb_otlElem"] =3D new TxtBtn( "nb_otl","nb_otlElem",parent.ToggleOt= lPane,GetOtlState ) gBtnArr["nb_nts"] =3D new ImgBtn( "nb_nts","nb_ntsBorder",10,parent.ToggleN= tsPane ) gBtnArr["nb_nts"].SetActive =3D _BSetA_BorderImg; gBtnArr["nb_nts"].SetInactive =3D _BSetI_BorderImg; gBtnArr["nb_ntsBorder"] =3D new TxtBtn( "nb_ntsBorder","nb_ntsElem",parent.= ToggleNtsPane,GetNtsState ) gBtnArr["nb_ntsElem"] =3D new TxtBtn( "nb_ntsBorder","nb_ntsElem",parent.To= ggleNtsPane,GetNtsState ) gBtnArr["nb_prevBorder"] =3D gBtnArr["nb_prev"]=3D new ImgBtn( "nb_prev","n= b_prevBorder",30,parent.GoToPrevSld ) gBtnArr["nb_nextBorder"] =3D gBtnArr["nb_next"]=3D new ImgBtn( "nb_next","n= b_nextBorder",30,parent.GoToNextSld ) gBtnArr["nb_sldshw"]=3D new ImgBtn( "nb_sldshw","nb_sldshwBorder",18,parent= .FullScreen ) gBtnArr["nb_sldshwBorder"] =3D new TxtBtn( "nb_sldshw","nb_sldshwBorder",pa= rent.FullScreen,null ) gBtnArr["nb_sldshwBorder"].SetActive =3D _BSetA_Border; gBtnArr["nb_sldshwBorder"].SetInactive =3D _BSetI_Border; gBtnArr["nb_sldshwText"] =3D new TxtBtn( "nb_sldshw","nb_sldshwText",parent= .FullScreen,null ) gBtnArr["nb_sldshwText"].SetActive =3D _BSetA_Border; gBtnArr["nb_sldshwText"].SetInactive =3D _BSetI_Border; gBtnArr["nb_voice"] =3D gBtnArr["nb_voiceBorder"] =3D new ImgBtn( "nb_voice= ","nb_voiceBorder",18,parent.ToggleVNarration ) gBtnArr["nb_otlTxtBorder"] =3D gBtnArr["nb_otlTxt"]=3D new ImgBtn( "nb_otlT= xt","nb_otlTxtBorder",23,parent.ToggleOtlText ) gBtnArr["nb_ntsBorder"].m_flagId=3D "nb_nts" gBtnArr["nb_ntsBorder"].SetFlag =3D NtsBtnSetFlag gBtnArr["nb_otlTxt"].ChangeIcon=3D GetOtlTxtState /********************************************* Context menu implementation _CM() is the function that's hooked up to the oncontextmenu event. Once we're asked to show the menu, we first build it by creating DIVs on-the-fly. Then we position it=20 within the screen area so it doesn't get clipped. Creating the DIVs using createElement() means we don't have to write out any extra HTML into the slide HTML files. **********************************************/ var sNext=3D"Successivo",sPrev=3D"Precedente",sEnd=3D"Fine presentazione",s= Font=3D"Arial",sArrow=3D"Freccia",sFreeform=3D"Figura a mano libera",sRect= =3D"Rettangolo",sOval=3D"Ovale" function ShowMenu() { BuildMenu(); var doc=3DPPTSld.document.body,x=3DPPTSld.event.clientX+doc.scrollLeft,y= =3DPPTSld.event.clientY+doc.scrollTop m =3D PPTSld.document.all.item("ctxtmenu") m.style.pixelLeft=3Dx if( (x+m.scrollWidth > doc.clientWidth)&&(x-m.scrollWidth > 0) ) m.style.pixelLeft=3Dx-m.scrollWidth m.style.pixelTop=3Dy if( (y+m.scrollHeight > doc.clientHeight)&&(y-m.scrollHeight > 0) ) m.style.pixelTop=3Dy-m.scrollHeight m.style.display=3D"" } function _CM() { if( !parent.IsFullScrMode() ) return; if(!PPTSld.event.ctrlKey) { ShowMenu() return false } else HideMenu() } function BuildMenu() { if( PPTSld.document.all.item("ctxtmenu") ) return var mObj=3DCreateItem( PPTSld.document.body ) mObj.id=3D"ctxtmenu" mObj.style.visibility=3D"hidden" var s=3DmObj.style s.position=3D"absolute" s.cursor=3D"default" s.width=3D"120px" SetCMBorder(mObj,"menu","black") var iObj=3DCreateItem( mObj ) SetCMBorder( iObj, "threedhighlight","threedshadow" ) iObj.style.padding=3D2 CreateMenuItem( iObj,sNext,M_GoNextSld,M_True ) CreateMenuItem( iObj,sPrev,M_GoPrevSld,M_HasPrevSld ) =09 CreateSeparator( iObj ) CreateMenuItem( iObj,sEnd,M_End,M_True ) mObj.style.visibility=3D"visible" } function Cancel() { window.event.cancelBubble=3Dtrue; window.event.returnVa= lue=3Dfalse } function Highlight() { ChangeClr("activecaption","threedhighlight") } function Deselect() { ChangeClr("threedface","menutext") } function Perform() { e=3DPPTSld.event.srcElement if( e.type=3D=3D"menuitem" && e.IsActive() ) e.Action() else PPTSld.event.cancelBubble=3Dtrue } function ChangeClr( bg,clr ) { e=3DPPTSld.event.srcElement if( e.type=3D=3D"menuitem" && e.IsActive() ) { e.style.backgroundColor=3Dbg e.style.color=3Dclr } } function M_HasPrevSld() { return( parent.HasPrevSld() ) } function M_GoNextSld() { if( gIsEndShow ) M_End(); else GoToNextSld() } function M_GoPrevSld() { if( gIsEndShow ) { gIsEndShow=3D0; history.back();= PPTSld.event.cancelBubble=3Dtrue; } else GoToPrevSld() } function M_True() { return true } function M_End() { window.close( self ) } function CreateMenuItem( node,text,action,eval ) { var e=3DCreateItem( node ) e.type=3D"menuitem" e.Action=3Daction e.IsActive=3Deval e.innerHTML=3Dtext if( !e.IsActive() ) e.style.color=3D"threedshadow" e.onclick=3DPerform e.onmouseover=3DHighlight e.onmouseout=3DDeselect s=3De.style; 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charset="us-ascii" Diapositiva 1 ------=_NextPart_01C9B6B6.B4E5C530 Content-Location: file:///C:/2B393234/presentazionepowerpoint_file/outline.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="us-ascii"

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